Académicos

Dr. Edgar Pastene Navarrete
Doctor en Farmacología
ORCID: https://orcid.org/0000-0001-5437-9210
Área de investigación:
Química y Farmacología de productos naturales
Laboratorio de Síntesis y Biotransformación de Productos Naturales
Contacto:
epastene@ubiobio.cl / +56-42-246
Publicaciones 2021 – 2026
2026
Correa-Otero, D., Fiallos, N., Gómez-Mediavilla, Á., López, M. G., Siguero-Gómez, C., Bustamante, L., Alarcón-Enos, J., & Pastene-Navarrete, E. (2026). Alkaloids from in vitro cultured Rhodophiala pratensis display neuroprotective effects in murine microglial cell models of inflammation. Plants, 15(8), 1186. https://doi.org/10.3390/plants15081186
2025
Jara-Zapata, P., Arancibia-Ávila, P., Valladares, M. A., Torres-Díaz, C., Pastene, E., & Reyes-Quinteros, N. (2025). Bioprospecting of Chilean Labyrinthulomycetes: Laboratory evaluation of PUFA and carotenoid production in isolates from diverse natural environments. Journal of Eukaryotic Microbiology, 72(5), e70035. https://doi.org/10.1111/jeu.70035
Jara-Zapata, P., Arancibia-Ávila, P., Valladares, M. A., Torres-Díaz, C., Pastene, E., & Reyes-Quinteros, N. (2025). First record of Aplanochytrium on the Chilean coast and its biotechnological potential: Expanding the geographic distribution of Labyrinthulomycetes. Journal of Eukaryotic Microbiology, 72(2), e70007. https://doi.org/10.1111/jeu.70007
Fiallos, N., Acuña, S., Correa-Otero, D., Venegas-Toloza, M., Beldarrain, T., Burgos, J., Fuentes, F., Bustamante, F., Christiansen, G., Roa, V., Schott, E., Alarcón-Enos, J., & Pastene-Navarrete, E. (2025). Centrifugal partition chromatography is a powerful tool for the isolation of antibiofilm quantum carbon dots synthesized by hydrothermal treatment of avocado peels. Molecules, 30(7), 1525. https://doi.org/10.3390/molecules30071525
2024
Arias-Santé, M. F., Fuentes, J., Ojeda, C., Aranda, M., Pastene, E., & Speisky, H. (2024). Amplification of the antioxidant properties of myricetin, fisetin, and morin following their oxidation. Food Chemistry, 435, 137487. https://doi.org/10.1016/j.foodchem.2023.137487
Pettinelli, N., Sabando, C., Bouza Padín, R., Rodríguez-Díaz, M., Pastene, E., Mora, L., Pascual, G., Carrillo-Varela, I., Jara, N., Ide, W., & Rodríguez-Llamazares, S. (2024). Bioactive extracts from grape (Vitis vinifera L. cv. País) leaves: Characterization and encapsulation in poly-3-hydroxybutyrate-co-3-valerate microparticles. Food Bioscience, 59, 103968. https://doi.org/10.1016/j.fbio.2024.103968
Pastene-Burgos, S., Muñoz-Núñez, E., Quiroz-Carreño, S., Pastene-Navarrete, E., Espinoza Catalán, L., Bustamante, L., & Alarcón-Enos, J. (2024). Ceanothanes derivatives as peripheric anionic site and catalytic active site inhibitors of acetylcholinesterase: Insights for future drug design. International Journal of Molecular Sciences, 25(13), 7303. https://doi.org/10.3390/ijms25137303
Muñoz-Núñez, E., Pastene-Navarrete, E., Quiroz-Carreño, S., Céspedes-Acuña, C., & Madrid-Villegas, A. (2024). Insecticidal, antifeedant and acetylcholinesterase inhibitory activity of sesquiterpenoids derived from eudesmane, their molecular docking and QSAR. Pesticide Biochemistry and Physiology, 201, 105841. https://doi.org/10.1016/j.pestbp.2024.105841
Berrios-Henríquez, B., Venegas-Toloza, M., Reyes-Fuentes, M., Zúñiga-Arbalti, F., Bustamante, L., García-Cancino, A., Alarcón-Enos, J., & Pastene-Navarrete, E. (2024). Synthesis and isolation of phenol- and thiol-derived epicatechin adducts prepared from avocado peel procyanidins using centrifugal partition chromatography and the evaluation of their antimicrobial and antioxidant activity. Molecules, 29(12), 2872. https://doi.org/10.3390/molecules29122872
2023
Pastene, E., Venegas, M., Fonseca, K., García, A., Zúñiga, F., Alarcón, J., Fiallos, N., Christiansen, G., Correa, D., Bustamante, L., & Avello, M. (2023). Workflow for bio-guided fractionation of antimicrobial polyphenols from Ugni molinae leaves using microfractionation and centrifugal partition chromatography: In vitro and in silico studies. Journal of the Chilean Chemical Society, 68(4), 5977–5986. https://doi.org/10.4067/S0717-97072023000405977
Avello, M., Fernández, M., Fernández, P., Torres, E., & Pastene, E. (2023). Desarrollo inicial de un fitofármaco derivado del jugo de Citrus limon (limón) para el tratamiento de crisis hipertensivas. Revista Chilena de Cardiología, 42(2), 82–89. https://doi.org/10.4067/S0718-85602023000200082
2022
Contreras-Machuca, P. I., Avello, M., Pastene, E., Machuca, Á., Aranda, M., Hernández, V., & Fernández, M. (2022). Chemical characterization and microencapsulation of extracellular fungal pigments. Applied Microbiology and Biotechnology, 106(24), 8021–8034. https://doi.org/10.1007/s00253-022-12255-9
Quiroz-Carreño, S., Muñoz-Núñez, E., Silva, F. L., Devotto-Moreno, L., Seigler, D. S., Pastene-Navarrete, E., Céspedes-Acuña, C. L., & Alarcón-Enos, J. (2022). Cyclopeptide alkaloids from Discaria chacaye (Rhamnaceae) as result of symbiosis with Frankia (Actinomycetales). Chemistry & Biodiversity, 19(9), e202200630. https://doi.org/10.1002/cbdv.202200630
Alarcón-Enos, J., Muñoz-Núñez, E., Gutiérrez, M., Quiroz-Carreño, S., Pastene-Navarrete, E., & Céspedes-Acuña, C. (2022). Dihydro-β-agarofurans natural and synthetic as acetylcholinesterase and COX inhibitors: Interaction with the peripheral anionic site (AChE-PAS), and anti-inflammatory potentials. Journal of Enzyme Inhibition and Medicinal Chemistry, 37(1), 1845–1856. https://doi.org/10.1080/14756366.2022.2091554
Muñoz-Núñez, E., Quiroz-Carreño, S., Pastene-Navarrete, E., Seigler, D. S., Céspedes-Acuña, C., Martínez Valenzuela, I., Oppliger Muñoz, M., Salas-Burgos, A., & Alarcón-Enos, J. (2022). Assessments of ceanothanes triterpenes as cholinesterase inhibitors: An investigation of potential
agents with novel inspiration for drug treatment of neurodegenerative diseases. Metabolites, 12(7), 668. https://doi.org/10.3390/metabo12070668
Correa, D. I., Pastene-Navarrete, E., Baeza, M., Bustamante, L., & Alarcón-Enos, J. (2022). Effect of plant growth regulators on alkaloid production in cell cultures of Chilean Amaryllidaceae: Rhodophiala pratensis, Rhodophiala splendens, Rhodophiala advena, and Rhodolirium speciosum. Plant Cell, Tissue and Organ Culture, 151(3), 521–534. https://doi.org/10.1007/s11240-022-02368-4
Trujillo-Mayol, I., Viegas, O., Sobral, M. M. C., Casas-Forero, N., Fiallos, N., Pastene-Navarrete, E., Faria, M. A., Alarcón-Enos, J., Pinho, O., & Ferreira, I. M. P. L. V. O. (2022). In vitro gastric bioaccessibility of avocado peel extract in beef and soy-based burgers and its impact on Helicobacter pylori risk factors. Food Chemistry, 373, 131505. https://doi.org/10.1016/j.foodchem.2021.131505
Silva, F. L., Quiroz-Carreño, S., Ferreira, M. J. P., Wei, Z.-J., Thakur, K., Lv, X., Avila-Acevedo, J. G., Kubo, I., Seigler, D. S., Zengin, G., Sinan, K. I., Mollica, A., Alarcón-Enos, J., Pastene-Navarrete, E., & Céspedes-Acuña, C. L. (2022). Exploring the potential of Fabiana imbricata Ruiz et Pav. (“Pichi”) against pest insects and pathogenic microorganisms for crop protection. South African Journal of Botany, 151, 114–127.
2021
Torres-Vega, J., Gómez-Alonso, S., Pérez-Navarro, J., Alarcón-Enos, J., & Pastene-Navarrete, E. (2021). Polyphenolic compounds extracted and purified from Buddleja globosa Hope (Buddlejaceae) leaves using natural deep eutectic solvents and centrifugal partition chromatography. Molecules, 26(8), 2192. https://doi.org/10.3390/molecules26082192
Del Campo, A., Salamanca, C., Fajardo, A., Díaz-Castro, F., Bustos, C., Calfío, C., Troncoso, R., Pastene-Navarrete, E. R., Acuna-Castillo, C., Milla, L. A., Villarroel, C. A., Cubillos, F. A., Aranda, M., & Rojo, L. E. (2021). Anthocyanins from Aristotelia chilensis prevent olanzapine-induced hepatic-lipid accumulation but not insulin resistance in skeletal muscle cells. Molecules, 26(20), 6149. https://doi.org/10.3390/molecules26206149
Hermosilla, J., Pastene-Navarrete, E., & Acevedo, F. (2021). Electrospun fibers loaded with natural bioactive compounds as a biomedical system for skin burn treatment: A review. Pharmaceutics, 13(12), 2054. https://doi.org/10.3390/pharmaceutics13122054
Proyectos Externos:
Investigador Responsable:
FONDECYT Regular 1250479 (2025-2029): Expanding the chemical space of thiol-derived polyphenols using multi-nucleophile reactions to obtain new molecules targeting c-di-AMP receptors: Empowering drug discovery by comparative metabolomics and ionomics approaches in biofilm-forming bacteria
Co-Investigador:
FONDECYT 1250113 (2025-2029): Regular Design, Synthesis, and Evaluation of Natural Pentacyclic Triterpenoids Derivatives via a Combination of Chemical and Microbial Modification as Enzyme Inhibitor: A route to new bioactive compounds
FONDECYT Regular 1241988 (2024-2027): Elucidating a possible transmission vector for Helicobacter pylori: stressing factors involved in its exit from Candida albicans and the mechanisms involved in the entry and exit of this bacterium from the yeast.
Fortalecimiento Al Desarrollo Científico Tecnológico De Centros Regionales R23F0005 (2024-2027): RECYCLE-SAFE: Advanced sustainable and safe solutions for recycling plastic packaging.