Académicos

Dr. Julio Alarcón Enos
Doctor en Ciencias con mención en Química.
ORCID: https://orcid.org/0000-0001-7473-8823
Área de investigación:
Química de productos naturales
Actividad biológica
Química médica.
Laboratorio de Biotecnología y Genética de los alimentos (BGA)
Contacto:
jualarcon@ubiobio.cl / +56-42-2463381
Publicaciones 2021 – 2026
2021
Trujillo-Mayol, I., Casas-Forero, N., Pastene-Navarrete, E., Lima Silva, F., & Alarcón-Enos, J. (2021). Fractionation and hydrolyzation of avocado peel extract: Improvement of antibacterial activity. Antibiotics, 10(1), 23. https://doi.org/10.3390/antibiotics10010023
Torres-Vega, J., Gómez-Alonso, S., Pérez-Navarro, J., Alarcón-Enos, J., & Pastene-Navarrete, E. (2021). Polyphenolic compounds extracted and purified from Buddleja globosa Hope (Buddlejaceae) leaves using natural deep eutectic solvents and centrifugal partition chromatography. Molecules, 26(8), 2192. https://doi.org/10.3390/molecules26082192
Trujillo-Mayol, I., Sobral, M. M. C., Viegas, O., Cunha, S. C., Alarcón-Enos, J., Pinho, O., & Ferreira, I. M. P. L. V. O. (2021). Incorporation of avocado peel extract to reduce cooking-induced hazards in beef and soy burgers: A clean label ingredient. Food Research International, 147, 110434. https://doi.org/10.1016/j.foodres.2021.110434
Trujillo-Mayol, I., Guerra-Valle, M., Casas-Forero, N., Sobral, M. M. C., Viegas, O., Alarcón-Enos, J., Ferreira, I. M. P. L. V. O., & Pinho, O. (2021). Western dietary pattern antioxidant intakes and oxidative stress: Importance during the SARS-CoV-2/COVID-19 pandemic. Advances in Nutrition, 12(3), 670–681. https://doi.org/10.1093/advances/nmaa171
2022
Trujillo-Mayol, I., Viegas, O., Sobral, M. M. C., Casas-Forero, N., Fiallos, N., Pastene-Navarrete, E., Faria, M. A., Alarcón-Enos, J., Pinho, O., & Ferreira, I. M. P. L. V. O. (2022). In vitro gastric bioaccessibility of avocado peel extract in beef and soy-based burgers and its impact on Helicobacter pylori risk factors. Food Chemistry, 373, 131505. https://doi.org/10.1016/j.foodchem.2021.131505
Astudillo-Neira, R., Muñoz-Nuñez, E., Quiroz-Carreno, S., Avila-Stagno, J., & Alarcon-Enos, J. (2022). Bioconversion in ryegrass-fescue hay by Pleurotus ostreatus to increase their nutritional value for ruminant. Agriculture, 12(4), 534. https://doi.org/10.3390/agriculture12040534
Correa, D. I., Pastene-Navarrete, E., Baeza, M., Bustamante, L., & Alarcón-Enos, J. (2022). Effect of plant growth regulators on alkaloid production in cell cultures of Chilean Amaryllidaceae: Rhodophiala pratensis, Rhodophiala splendens, Rhodophiala advena, and Rhodolirium speciosum. Plant Cell, Tissue and Organ Culture, 151, 521–534. https://doi.org/10.1007/s11240-022-02368-4
Muñoz-Núñez, E., Quiroz-Carreño, S., Pastene-Navarrete, E., Seigler, D. S., Céspedes-Acuña, C. L., Martínez-Valenzuela, I., Oppliger-Muñoz, M., Salas-Burgos, A., & Alarcón-Enos, J. (2022). Assessments of ceanothanes triterpenes as cholinesterase inhibitors: An investigation of potential agents with novel inspiration for drug treatment of neurodegenerative diseases. Metabolites, 12(7), 668. https://doi.org/10.3390/metabo12070668
Alarcón-Enos, J., Muñoz-Núñez, E., Gutiérrez, M., Quiroz-Carreño, S., Pastene-Navarrete, E., & Céspedes-Acuña, C. (2022). Dyhidro-β-agarofurans natural and synthetic as acetylcholinesterase and COX inhibitors: Interaction with the peripheral anionic site (AChE-PAS), and anti-inflammatory potentials. Journal of Enzyme Inhibition and Medicinal Chemistry, 37(1), 1845–1856. https://doi.org/10.1080/14756366.2022.2091554
Quiroz-Carreño, S., Muñoz-Nuñez, E., Silva, F. L., Devotto-Moreno, L., Seigler, D. S., Pastene-Navarrete, E., Céspedes-Acuña, C. L., & Alarcón-Enos, J. (2022). Cyclopeptide alkaloids from Discaria chacaye (Rhamnaceae) as result of symbiosis with Frankia (Actinomycetales). Chemistry & Biodiversity, 19(9), e202200630. https://doi.org/10.1002/cbdv.202200630
Zengin, G., Dall’Acqua, S., Sinan, K. I., Uba, A. I., Sut, S., Peron, G., Etienne, O. K., Kumar, M., Céspedes-Acuña, C. L., Alarcon-Enos, J., Mollica, A., & Mahomoodally, M. F. (2022). Gathering scientific evidence for a new bioactive natural ingredient: The combination between chemical profiles and biological activities of Flueggea virosa extracts. Food Bioscience, 49, 101967. https://doi.org/10.1016/j.fbio.2022.101967
2023
López-Acosta, O., Ruiz-Ramírez, A., Barrios-Maya, M.-Á., Alarcon-Aguilar, J., Alarcon-Enos, J., Céspedes-Acuña, C. L., & El-Hafidi, M. (2023). Lipotoxicity, glucotoxicity and some strategies to protect vascular smooth muscle cell against proliferative phenotype in metabolic syndrome. Food and Chemical Toxicology, 172, 113546. https://doi.org/10.1016/j.fct.2022.113546
Astudillo-Neira, R., Suescun-Ospina, S., Vera-Aguilera, N., Alarcón-Enos, J., & Ávila-Stagno, J. (2023). Biodegraded hay with graded addition of Pleurotus ostreatus improves dry matter disappearance and reduces methane production of diets incubated in vitro. Italian Journal of Animal Science, 22(1), 1–10. https://doi.org/10.1080/1828051X.2023.2193607
2024
Berrios-Henríquez, B., Venegas-Toloza, M., Reyes-Fuentes, M., Zúñiga-Arbalti, F., Bustamante, L., García-Cancino, A., Alarcón-Enos, J., & Pastene-Navarrete, E. (2024). Synthesis and isolation of phenol- and thiol-derived epicatechin adducts prepared from avocado peel procyanidins using centrifugal partition chromatography and the evaluation of their antimicrobial and antioxidant activity. Molecules, 29(12), 2872. https://doi.org/10.3390/molecules29122872
Pastene-Burgos, S., Muñoz-Núñez, E., Quiroz-Carreño, S., Pastene-Navarrete, E., Espinoza Catalan, L., Bustamante, L., & Alarcón-Enos, J. (2024). Ceanothanes derivatives as peripheric anionic site and catalytic active site inhibitors of acetylcholinesterase: Insights for future drug design. International Journal of Molecular Sciences, 25(13), 7303. https://doi.org/10.3390/ijms25137303
Zhang, W. W., Liang, Y. C., Thakur, K., Zhang, J. G., Vidal-San Martin, C., Bastias-Montes, J. M., Neira-Hinojosa, J. Y., Mah, S. H., Zengin, G., Saleem, H., El-Hafidi, M., Avila-Acevedo, J. G., Alarcon-Enos, J., & Céspedes-Acuña, C. L. (2024). Aqueous extract of pulp of maqui-berry (Aristotelia chilensis (Mol.) Stuntz) induces apoptosis in human endometrial carcinoma Ishikawa cells via mitochondrial and endoplasmic reticulum stress pathways. Food Bioscience, 61, 104733. https://doi.org/10.1016/j.fbio.2024.104733
2025
Muñoz-Núñez, E., Madrid-Villegas, A., Alarcón-Enos, J., Ferreira-Funes, C., Valdés-Navarro, F., Santander, R., Norambuena-Morales, J., & Martínez-Lobos, M. (2025). Insecticidal potential of Baccharis macraei essential oils: An ecological approach to their volatile composition in insect management. Agronomy, 15(3), 509. https://doi.org/10.3390/agronomy15030509
Fiallos, N., Acuña, S., Correa-Otero, D., Venegas-Toloza, M., Beldarrain, T., Burgos, J., Fuentes, F., Bustamante, F., Christiansen, G., Roa, V., Schott, E., Alarcón-Enos, J., & Pastene-Navarrete, E. (2025). Centrifugal partition chromatography is a powerful tool for the isolation of antibiofilm quantum carbon dots synthesized by hydrothermal treatment of avocado peels. Molecules, 30(7), 1525. https://doi.org/10.3390/molecules30071525
2026
Correa-Otero, D., Fiallos, N., Gómez-Mediavilla, Á., López, M. G., Siguero-Gómez, C., Bustamante, L., Alarcón-Enos, J., & Pastene-Navarrete, E. (2026). Alkaloids from in vitro cultured Rhodophiala pratensis display neuroprotective effects in murine microglial cell models of inflammation. Plants, 15(8), 1186. https://doi.org/10.3390/plants15081186
Avila-Acevedo, J. G., López-Pérez, M. A., Villagómez-Guzmán, A. K., Estrella-Parra, E. A., Álvarez-Santos, N., Valencia-Quiroz, I., Orozco-Martínez, J., López-Villafranco, M. E., Aguilar-Rodríguez, S., Céspedes-Acuña, C. L., Alarcón-Enos, J., & García-Bores, A. M. (2026). Lippia umbellata Cav.: Chemical composition, insecticidal, and antimicrobial activities. Chemistry & Biodiversity, 23(8), e71548. https://doi.org/10.1002/cbdv.71548